Obeid H*, Pavy B1, Hallab M2, Darchis J1, Merle E1, Caillon M1
Réadaptation cadiovasculaire, centre hospitalier loire vendée océan, Machecoul
Gerontology department, university, Nantes, France
Obeid H1,2, Stergiopulos N3, Hallab M4, Mousseaux E2, Boutouyrie P2, Laurent S2, Segers P1
1 IBiTech-bioMMeda, ELIS department, iMinds Medical IT, Ghent University, Ghent, Belgium.
2 Hôpital Européen Georges-Pompidou, Inserm
U970, Paris, France.
3 Laboratory of Hemodynamics and Cardiovascular Technology, Ecole Polytechnique Fédérale de Lausanne EPFL,
4 Axelife and University hospital Nantes, Nantes, France.
Obeid H1,2 ,Khettab H1, Hallab M3, Boutouyrie P1,2, Laurent S1,2
1Inserm U970, Paris, France
2 Paris Descartes University, Paris, France
3 Gerontology Department, Nantes University, Nantes, France
Ba A1, Touré M1, Ouedraogo V1, Diaw M1, Sow A1, Hounjo S1, Seck A1, Sar F2, Gueye L3, Samb A1, Hallab M4 and Leftheriotis G5.
1 Laboratoire de Physiologie et d’Explorations Fonctionnelles / Faculté de Médecine, de Pharmacie et d’Odontologie (FMPO), UMI 3189 UCAD, CNRST / Université Cheikh Anta Diop / Dakar / SENEGAL
2 Laboratoire de Physiologie et d’Explorations Fonctionnelles / UFR de sante / UMI 3189 UCAD, CNRST / Université de Thies / Thies / SENEGAL
3 Université Alioune Diop de Bambey / UMI 3189 UCAD, CNRST / Diourbel / SENEGAL
4 Hôpital Universitaire de Nantes, Place Ricordeau, 44000 Nantes – France
5 Laboratoire de Biologie Neuro-vasculaire et Mitochondriale Intégrée UMR CNRS 6214 – Inserm 1083, Faculté
de Médecine Angers, 49045 Angers – France.
pOpmètre® is a simple and practical tool, highlighted an increase in arterial stiffness in patients with SSc by measuring the ft-PWV. It could play a role in this disease monitoring and in prediction of cardiovascular complications.
V Ouédraogo1, M Hallab2, I Signolet3, M Diaw1, A Ba1, G Lefthériotis3.
1University Cheick Anta Diop, Dakar, Senegal.
2University hospital, Nantes, France.
3 University Hospital, Angers, France.
- A high arterial stiffness level was associated with Sickel Cell trait carriers, especially in sedentary patients.
- Exercise training exerts a beneficial effect on Arterial Stiffness.
- Arterial Stiffness is associated with viscosity.
H Obeid1,2, H Khettab1,2, M Hallab3, P Boutouyrie1,2,S Laurent1,2
1 Inserm U970, Paris, France
2 Paris Descartes University and Hôpital Européen Georges Pompidou, Paris, France
3 Gerontology Department, Nantes University, Nantes, France
Conclusion: pOpmètre® with optimized algorithm and procedure qualifies as excellent agreement with the reference technique for PWV asse ssment Compared to CF PWV, FT PWV is faster, simpler to perform and importantly, more acceptable to patients, however, outcome studies must confirm the value of this new device.
F Thomas5, H Obeid1,2, P Boutouyrie1,2,3, M Hallab4, P Coucke5, N Danchin5, B Pannier5
1 Inserm U970, Paris, France
2 Paris Descartes University, Paris, France
3 Hôpital Européen Georges Pompidou
4 Gerontology Department, Nantes University, Nantes, France
5 IPC, Paris, France


Conclusion: The very simple and quick measurement of finger to toe arterial stiffness with the pOpmètre® device, can be performed by nurses during a tight time schedule. It provides values within aortic Reference value ranges. It appears as a promising substitute to reference techniques with the advantage of simplicity for assessing PWV during standard health check-up.

7 - Arterial stiffness measured with pOpmètre® in primary anti-phospholipids syndrome.

M Hallab1, G Bourgeais2, A Labonde2, G Leftheriotis2, C Belizna2
 University Hospital of Nantes, France.
2 University Hospital of Angers, France.


Conclusion: In the APS patients, the arterial stiffness measured by pOpmètre, is increased compared with controls and correlated with arterial stiffness and IMT measured by Doppler ultrasound.

6 - Pulse Wave Velocity with pOpmetre® independently correlates with glomerular filtration rate in renal transplant patients.

M Hallab1, S Bertin2, P Gatault2, C Barbet2, Y Lebranchu2, M Buchier2, JM Halimi2
1 Department of geriatrics, CHU de Nantes, France.
2 Department of Nephrology, CHU de Tours, France.

Conclusions: Glomerular filtration rate independently correlates with pulse wave velocity in renal transplant patients, supporting the hypothesis that kidney function plays a predominant role in arterial stiffness.

4 - Outpatient measurement of arterial stiffness in patients with type 2 diabetes and obesity.

Journal of Diabetes, 2016

Mohammedi K1,2, Compaore A2, Potier L1,2,3, Belhatem N1,2, Feron M2, Matallah N1,2, Travert F1,2,3, Hansel B1,2,3, Velho G1, Roussel R1,2,3, Hallab M4, Marre M1,2,3

1 INSERM, UMR_S 1138, Centre de recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
Assistance Publique Hôpitaux de Paris, Bichat Hospital, DHU FIRE, Department of Diabetoology, Endocrinology and Nutrition, 46 rue Henri Huchard, 75018 Paris, France.
3 University Paris-Diderot, Sorbonne Pairs Cité, UFR de Médecine, 16 rue Henri Huchard, 75018 Paris, France
4 Department of Gerontology University Hospital of Nantes, Nantes, France.

Conclusion: The outpatient-measured ftPWV was correlated with age, systolic blood pressure and ankle-brachial index. It was higher in patients with T2DM and obesity compared to healthy controls. The highest ftPWV was observed in patients with both T2DM and obesity. This article is protected by copyright. All rights reserved.

4 - Arterial stiffness measured by pOpmètre® system: relationship to carotid plaque.

M Hallab 1, C Terrier-Barbeau 2, M Legrand 2, PH Ducluzeau 3, M Colette 4, G Leftheriotis 2, G Berrut 1.
1 Department of gerontology, University hospital Nantes FRANCE
2 Laboratory of vascular Investigations, University Hospital Angers FRANCE
3 Department of diabetology and nutrition, University Hospital Angers FRANCE
4 Laboratory of Engineering and automated systems University Angers FRANCE  

Conclusions : In this population with risk factors, stiffness indices measured by pOpmètre® provide information on the level of atherosclerosic impact in the peripheral vasculature. These indices correlated with ageing.

3 - Does the aortic valves correspond to a stable anatomical landmark ?

Hallab M.1, Dahou A.2, Chevalet P.1, Berrut G1.
1Hôpital Bellier CHU de Nantes, Nantes, France, 2Service de Radiologie CHU de Nantes, Nantes, France.


- The AV-HD distance projects to a constant anatomical landmark (i.e. the hyoid bone)
- The size of this arterial segment is significantly correlated to the height of the subjects.
- These preliminary results could be useful for a more accurate determination of the pulse wave velocity.
Artery 11° october 2011.

2 - A new index to evaluate arterial ageing independently of arterial blood pressure: pOpscore®.

M Hallab, JM Boin, M Tramblay, P Chevalet. Hôpital Bellier – CHU de Nantes – 44000 Nantes.

- All variables were correlated to age and blood pressure.
- pOpscore® is related only to ageing independently from blood pressure.
- pOpmètre® is a promising technique for the routine determination of vascular ageing in primary care medicine.
Artery 11° October 2011.

1 - A novel device for measuring arterial stiffness using the finger-toe pulse wave velocity: validation study of the pOpmètre®

1Alivon M, 1Vo-Duc PT, 1Vignon V, 2Bozec E, 1Khettab H, 4Hanon O, 1Boutouyrie P, 3Hallab M, 1Laurent S
1 INSERM U970, Assistance Publique Hôpitaux de Paris, Université Paris-Descartes, Paris, France.
2 CIC-INSERM Hôpital Vandeouvre les Nancy, Nancy, France.
3 Gerontology Department, Nantes University, Nantes, France.
4 Hôpital Broca de Paris, France.

Conclusions: The results of the present study indicate that ft-PWV may be a promising device to assess arterial stiffness. Probably, the greatest advantages of pOpmètre® are: a low price, an easy and fast way to measure. Further studies are needed to adjust the bias concerning peripheral stiffness and to validate the pOpmètre® in larger population.


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