The Innovation

pOpmètre system is a scientific innovation based on the following findings:

- The pulse wave velocity is not correlated with age in the upper limb while it is in the aorta and the lower limb [1].

- The complications of various diseases of vascular risk factors (hypertension, diabetes, hypercholesterolemia, tobacco) are located at the microcirculation: Kidney, heart, brain, eye, and small arteries of the lower limbs.

- The interaction between the small arteries and large arteries is an important consideration [2]. A virtuous circle causes an increase in the stiffness of large artery from the increase in mean arterial pressure, itself caused by the remodeling of arterioles, vasoconstriction induced, which is induced by the remodeling of large vessels and increased pulse pressure.

- pOpscore ® is a parameter correlated with age independently of blood pressure [3].

[1] Effect of Age on Brachial Artery Wall Properties Differs From the Aorta and Is Gender Dependent A Population Study Janneke J. van der Heijden-Spek, Jan A. Staessen, Robert H. Fagard, Arnold P. Hoeks, Harry A. Struijker Boudier, Luc M. Van Bortel  (Hypertension. 2000;35:637-642.)
[2] Anne-Isabelle Tropeano, Stéphane Laurent. Conséquences de l’atteinte vasculaire silencieuse au cours de l’hypertension artérielle et de l’hyperglycémie. Médecine thérapeutique Cardiologie. Volume 1, Numéro 3, 243-52, juillet-septembre 2003, Revue : Stress oxydant
[3] A new index to evaluate ageing independently of arterial blood pressure.: pOpscore®.  M Hallab, JM Boin, M Tramblay, P Chevalet. Hôpital Bellier – CHU de Nantes – 44000 Nantes. Artery research 2011 sous presse.
[4] Laurent et al Expert consensus document on arterial stiffness: methodological issues and clinical applications, on behalf of the European Network for Non-invasive Investigation of Large Arteries. Eur Heart J27 (21): 2588-2605.
[5] Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010; 55: 1318-1327.
[6] Boutouyrie et al. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values" European Heart Journal, 31(19), 2238-2250
[7] Van Bortel LM, Laurent S et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. Journal of Hypertension: 2012 - V 30 - 3 - 445–448.
[8] Reference Values for Arterial Stiffness' Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'. EurHeart J. 2010 Oct;31(19):2338-50.
[9] Ben-Shlomo, Y. et al., Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am CollCardiol. 2013 Nov 4. pii: S0735-1097(13)05974-3


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