Résumés des publications parues avec pOpmètre®.

CARLOS, Ramos Becerra, CARDONA-MÜLLER, David, CARDONA-MUÑOZ, Ernesto, et al. A18499 Evaluation of Central Aortic Blood Pressure and Pulse Wave Velocity in subjects with Ankylosing Spondylitis compared with healthy controls. Journal of Hypertension, 2018, vol. 36, p. e259.
Twenty-two patients with AS and 24 controls were included in our study, subjects with AS exhibited greater pSBP (p < 0.001), pDBP (p < 0.001), pPP (p < 0.001) and MBP (p < 0.001) compared to controls. Moreover, in the AS group we observed a higher ftPWV with a mean difference of 1.63 (p < 0.006, 95% CI of .50 to 2.7). No significant difference was observed in pPP. Subjects with ankylosing spondylitis showed increased ftPWV, central and peripheral blood pressure, this contributes to explain the higher risk of cardiovascular disease in this pathology.
SECK, Aissatou, AGNE, Fatou Diallo, SALL, Abibatou, et al. Insulin Resistance and Arterial Stiffness: Impact of Gestational Diabetes on Pulse Wave Velocity. In : ACTA PHYSIOLOGICA. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA : WILEY, 2018.
We recruited 60 pregnant women (G1), control group, included 25 normoglycemic pregnant (G2) included 35 women with Gestational Diabetes Mellitus (GDM). PWVft(G1: 5.99±1.23; G2:10.3±1.9; p˂0.0001) are significantly higher in diabetic group. PWVft is positively correlate to HOMAIR index Conclusion : Gestational diabetes might induce an increase of pulse wave velocity expressing increment of arterial stiffness. This last constitute an early underlying cardiovascular risk
VENARA, A., JAOUEN, R., LERMITE, E., et al. The Predictive Value of Pulse Wave Velocity for Anastomotic Leakage After Colorectal Surgery. World journal of surgery, 2019, vol. 43, no 1, p. 252-259.
tous les patients consécutifs opérés d’une résection colorectale programmée. Les patients étaient répartis en deux groupes selon la VOP mesurée par le pOpmètre® en période pré-opératoire: VOP+ (VOP>10m/s) et VOP- (VOP≤10m/s). Un total de 96 patients était identifié, 60 dans le groupe VOP- et 36 dans le groupe VOP+. Les patients VOP+ étaient plus à risque de présenter une FA que ceux VOP- (6.25% vs 0%) (p=0.002). Hormis la durée d’hospitalisation, il n’y avait pas de différence dans les complications opératoires immédiates entre les groupes. La VOP prédisait l’apparition d’une FA avec une sensibilité et une valeur prédictive négative de 100%. La mesure de la VOP pourrait être un examen prédictif dans le dépistage précoce des FA après chirurgie colorectale.
OBEID, Hasan, SOULAT, Gilles, MOUSSEAUX, Elie, et al. Numerical assessment and comparison of pulse wave velocity methods aiming at measuring aortic stiffness. Physiological measurement, 2017, vol. 38, no 11, p. 1953.
Purpose: To extend the existing 1D arterial network model (103 segments) of Reymond et al. to a more detailed model (143 segments) including the foot and hand circulation (radial and tibial arteries). The goal is to (i) extend the existing 1D arterial network model (103 segments) of Reymond et al. to a more detailed model (143 segments) including the foot and hand circulation (Radial and Tibial arteries); (ii) use the extending model as testing tool for pOpmètre® (finger–toe pulse wave velocity). The arterial tree dimensions and properties were taken from the literature and completed with data from patient scans. A non-linear viscoelastic constitutive law for the arterial wall was considered. Comparison of simulations with & without detailed hand and foot circulation demonstrate important differences in waveforme morphology in the distal beds. The completed model predicts pressure and flow waves in the hand and foot arteries which are in good qualitative agreement with the published in- vivo measurements. The correlation between ftPWV and aPWV was good and significant (R2 = 0.95). The Bland and Altman analysis, mean difference was 0.4 m/s, classifying the ftPWV as good agreement with reference method.
Obeid, H., Boutouyrie, P., Hallab, M., Khettab, H., & Laurent, S. (2018). Calculation of central blood pressure by analyzing the contour of the photoplethysmographic pulse measured at the finger with the pOpmètre® device. Archives of Cardiovascular Diseases Supplements, 10 (1), 104.
The objective is to establish a transfer function estimating the central blood pressure (CBP), calibrated with a brachial pressure cuff and using the parameters obtained with the contour analysis of the photoplethysmographic pulse measured with the pOpmètre® system. 69 subjects were included: 24 healthy subjects and 45 patients with essential hypertension aged 33 ± 8 years and 59 ± 17 years respectively. The correlation between the estimated central systolic pressure (CSP) and the reference one, was good and significant (R = 0.91 ; p<0.0001). A better correlation was found in terms of central diastolic pressure (CDP) (R = 0.92; p<0.0001). The Bland and Altman analysis, mean difference was 4 mmHg p<0.0001 (CSP) versus 3 mmHg p<0.0001 (CDP), the standard deviation of the difference was 5 mmHg (CSP) versus 4 mmHg (CDP), classifying the estimation as good agreement
Hasan Obeid, Hakim Khettab, Louise Marais, Magid Hallab, Stephane Laurent and Pierre Boutouyrie. Evaluation of arterial stiffness by finger^toe pulse wave velocity: optimization of signal processing and clinical validation.Journal of Hypertension. 35(8):1618-1625, August 2017.
101 patients, was to investigate different signal processing chains to improve the concordance of ft-PWV with the gold-standard cf-PWV. Finger–toe PWV (ft-PWV) was calculated using the four algorithms.The correlation between ft-PTT and carotid–femoral PTT was very good (r 2 = 0.81, P < 0.0001, RMSE = 5.4 ms)
OBEID, Hasan, OUEDRAOGO, Valentin, HALLAB, Magid. Arterial Stiffness: A New Biomarker to be Measured. Journal of Archives in Military Medicine, 2017, vol. 5, no 1.
State of the art, Revue about arterial stiffness. Devices, meanings, issues.
Measuring arterial stiffness with pOpmetre in cardiac rehabilitation program (Artery Research 2016). B. Pavy, H. Obeid, M. Hallab, J. Darchis, E. Merle, M. Caillon
Data from 100 consecutive patients recruited in a French CR centre. ftPWV was measured (pOpmètre-Axelife SAS-France) at the beginning and the end of CR (mean duration = 18.3±4 days). The patients (mean age 64±11 years), males = 84%, were coronary (51%), valvular (38%), heart failure (3%) and other (8%). The risk factors were the following : current smoking (n=3), Diabetes (n=26), high blood pressure (n=58), high cholesterol (n=48), obesity (n=15) and coronary heredity (n=19), sedentarity (n=20). The maximal workload (MWL) increased from 94.9±35 to 116±37 Watts and the 6min walking test (6MWT) from 430±113 to 505±106 m (p<0.0001). The PWV decreased from 9.16±3.0 to 8.39±2.5 m/s (p<0.008). Maximal physical capacity and 6MWT were dependant of the PWV and a current CR programme seems to improve the arterial stiffness in a cardiac population.
Mohammedi K, Potier L, Belhatem N, Feron M, Matallah N, Travert F, Hansel B, Velho G, Roussel R, Hallab M, Marre M. Outpatient measurment of arterial stiffness in patients with diabetes and obesity. Journal of diabetes. 2016.
A cross-sectional study was conducted in patients with obesity without T2DM (n=37), T2DM without obesity (n=40), T2DM plus obesity (n=43), and healthy controls (n=114). Outpatient measurements of the finger–toe PWV (ftPWV) were made. Mean ftPWV in controls and in patients with obesity, T2DM, and T2DM plus obesity was 8.32 ± 2.68, 9.50 ± 3.38, 11.29 ± 4.34, and 12.36 ± 6.67 m/s, respectively
(P < 0.0001). Outpatient-measured ftPWV was correlated with age, SBP, and ABI. It was higher in patients with T2DM and obesity compared with healthy controls. The highest ftPWV was observed in patients with both T2DM and obesity
Ba A., Touré M., Ouédraogo V., Diaw M., Sow A. K., Houndjo S. D., Loubano-voumbi G., Seck A., Sar F. B., Guèye L., Lefthériotis G., Samb A. and Hallab M. Arterial Stiffness Measured by Popmètre® in Patients with Systemic Sclerosis. J Phys Pharm Adv 2015, 5(10): 739-743
It was a descriptive and prospective study carried out with scleroderma patients and control subjects. Twenty patients and 26 controls were included in our study. Patients had higher heart rate (p = 0.038) and ft-PWV (p = 0.001).
Nine SCT carriers aged 32±9 years (7 men) were compared to 14 SCA subjects aged 29±9 years (2 men) and 22 control subjects aged 34±9 years. The cardiovascular risk (CVR) was assessed according to the Framingham Laurier score. The SCT carriers had a higher PWVft (m/s) than SCA subjects (8.2±2.2 vs 6.1±0.9m/s, P=0.004) but not different from that of healthy controls (8.2±2.2 vs 7.4±1.8m/s, P=0.33. Linear regression showed a positive relationship between PWVft and the pulse pressure (PP) (P˂0.001; r2=0.39; F=13.20). The results show that the SCT carriers have stiffer arteries than SCA subjects. Linear regressions adjusted for age, mean arterial pressure (MAP) and PP, showed that only age and PP were independently correlated with arterial stiffness in the entire population.
Ouédraogo, V.; Hallab, M.; Signolet, I.; Diaw, M.; Ba, A.; Leftheriotis, G. PP.06.17: ARTERIAL STIFFNESS MEASURED WITH POPMETRE(R) IN AFRICAN SICKLE CELL TRAIT CARRIERS. Journal of Hypertension. 33 -182, June 2015.
One hundred and four subjects (55 women, mean age 33.08 ± 11.52 years, BMI = 23 kg/m2) were enrolled in a prospective cross-sectional study. Subjects with SC (n = 78 aged 16 to 61 years) were compared to controls (AA, n = 26).
A high level arterial stiffness was associated with Sickel Cell trait carriers, especially in sedentary patients.Exercise training exerts a beneficial effect on arterial stiffness.
Obeid, H.; Boutouyrie, P.; Laurent, S.; Khettab, H.; Hallab, M. [PP.08.05] COMPARISON OF ARTERIAL STIFFNESS ASSESSED BY POPMETRE(R) WITH ARTERIAL STIFFNESS ASSESSED BY APPLANATION TONOMETRY: A CLINICAL STYDY. Journal of Hypertension: August 2017 – Volume 35 – Issue 8 – p 1618–1625.
45 subjects were included: 18 healthy subjects and 27 patients with essential hypertension aged 32 ± 7 years and 58 ± 18 years respectively. The correlation between FT PWV and CF PWV was good and significant (r2 = 0.77; p < 0.0001). A better correlation was found in terms of transit time (r2 = 0.83; p < 0.0001). The Bland and Altman analysis, mean difference was 0.35 m/s p < 0.0001 versus -11 ms p < 0.0001, the standard deviation of the difference was 0.87 m/s versus 6.73 ms, classifying the device as good agreement with reference (Wilkinson, ARTERY RES 2010). A significant bias persisted with underestimation in older subjects.
Hallab, M., Bertin, S., Gatault, P., Barbet, C., Lebranchu, Y., Buchler, M., & Halimi, J. M. (2014). 0438: Pulse wave velocity with pOpmetre® independently correlates with glomerular filtration rate in renal transplant patients. Archives of Cardiovascular Diseases Supplements, 6, 55.
Chez 44 transplantés reinaux, La VOP est positivement corrélée avec l’âge (r 2 = 0,16, p <0,009) et négativement avec la GFR (r 2 = 0,15, p <0,009). En utilisant un modèle de régression pas à pas (incluant le sexe, l’âge, la PAS, la PAD, la taille et le poids), seuls l’âge et la VOP restait significativement associé à la GFR.
Thomas-Jean, F., Obeid, H., Boutouyrie, P., Hallab, M., Coucke, P., Danchin, N., & Pannier, B. (09/2016). [PP. 11.22] ARTERIAL STIFFNESS RECORDINGS WITH POPMETRE (R) IN A GENERAL PRIMARY CARE POPULATION: THE IPC COHORT. Journal of Hypertension, 34, e183.
From September to December 2015, 332 subjects aged from 18 to 95 years had a standard health check-up at the IPC Center (Paris, France) including finger to toe pulse wave velocity recording with pOpmetre®, performed by nurses
Conclusion: The very simple and quick measurement of finger to toe arterial stiffness with the pOpmètre® device, can be performed by nurses during a tight time schedule.It provides values within aortic Reference value ranges.It appears as a promising substitute to reference techniques with the advantage of simplicity for assessing PWV during standard health check- up.
HALLAB, M., LEFTHERIOTIS, G., et BELIZNA, C. Arterial stiffness measured with pOpmètre® in primary anti-phospholipids syndrome. Artery Research, 2014, vol. 8, no 4, p. 135.
Chez 20 patients SAPL et 20 témoins ayant présenté une thrombose veineuse distale. Chez les SAPL, la RA mesurée par pOpmètre® est accrue par rapport aux témoins et est corrélée à la rigidité artérielle et à l’EIM mesurés en échographie doppler
Alivon M, Vo-Duc Phuong T, Vignon V et al. A novel device for measuring arterial stiffness using finger-toe pulse wave velocity: Validation study of the pOpmètre®.Arch Cardiovasc Dis. 2015;108(4):227-34. doi: 10.1016/j.acvd.2014.12.003
Comparaison entre la VOP par pOpmètreet celle par deux appareils Sphygmocor et Compliore chez 69 patients atteints de différentes pathologies (HTA, Danilos) et 17 normotendus, Une corrélation a été trouvée en termes de temps de transit (r2= 0,61, p < 0,0001) entre Sphygmocor et pOpmètre.
Regional and peripheral arterial stiffness measured by pOpmetre(®) in patients with Cvx risk factor, link with carotid plaques. M Hallab, M Collette, C Terrier-Barbeau, M Legrand, P H Ducluzeau, G Berrut, G Lefthériotis. ANCAAN62 (2013) 189–192 http://dx.doi.org/10.1016/j.ancard.2013.04.001
Chez 77 patients avec comme pathologie un syndrome metabolique. Les 25 patients avec plaques carotidiennes présentaient une VOP par pOpmètre plus élevée que chez les patients indemnes de plaques d’athérome carotidien (14,3 vs 10,7 m/s ; p<10- 4)
Arterial stiffness a new risk factor to measure. Magid Hallab, Sophie Pichierri, Pascal Chevalet, Laure De Decker, Gilles Berrut. Geriatrie et psychologie neuropsychiatrie du vieillissement 2012; 10(3):235-243.
Revue de la bibliographie concernant le vieillissement artériel et son intérêt chez la personne âgée.
A new index to evaluate arterial ageing independently of arterial blood pressure: pOpscore(®). M Hallab, S Pichierri, J-M Boin, M Tramblay, P Chevalet, G Berrut. ANCAAN 2012; 61(3):184-7.
Preuve du concepte : ce travail a démontré le lien entre l’âge, et la VOP (p<10-4) mesuré par pOpmètre chez 300 personnes.
Relationship between the aortic valves and an anatomical landmark using chest CT scan. Magid Hallab, Pascal Chevalet, Amine Dahou, Gilles Berrut. Artery Research 2012; 6: 55-57.
Ce travail concerne la validation et la preuve du concept. Rréalisé à partir de scanner cervico-thoracique chez 28 patients. Nous avons prouvé que l’arc aortique est de même longueur quela distance entre l’os Hyoïde les sigmoïdes aortiques ; et qu’il y a un lien entre la taille et la dimension de l’Aorte. Results:There was a correlation between the Aortic segment and the distance to the Hyoïd bone (non-parametric r = 0.66, p < 0.0001) and the AV-HD distance were positively correlated to the height of the subjects (r=0.60, p<0.002).


Les études avec pOpmètre® ont concerné 2034 personnes !

Aucun effet secondaire remarquable n’a été rapporté, différentes études cliniques en comparaison à la méthode standard ont montré une excellente concordance.

Par ailleurs, une étude scientifique par modélisation et fonction de Navier Stock ont validé scientifiquement les mesures entre le doigt et l’orteil par rapport avec ce qui se passe sur le trajet aortique avec un coefficient de corrélation à 0.95 %.

Les études dans différentes pathologie (hypertension, diabète, grossesse, drépanocytose, patients cardiaques, sclérodermie, Spondylartrite Ankylosante, chirurgie digestive… ) ont permis de distinguer les sujets mesurés en fonction de leur risque vasculaire,

Deux études prospectives ont montré la pertinence de la mesure dans la réadaptation cardiaque qui montre l’amélioration de la VOP après trois semaines de réadaptation avec une pratique sportive de 2 à 3 heures par jour. Cette amélioration était accompagnée d’un allongement de la distance de marche pendant 6 minutes, et en post opératoire en prédiction de complications avec une sensibilité et une valeur prédictive négative à 100%.

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