Numerical assessment and comparison of pulse wave velocity methods aiming at measuring aortic stiffness

Purpose: To extend the existing 1D arterial network model (103 segments) of Reymond et al. to a more detailed model (143 segments) including the foot and hand circulation (radial and tibial arteries). The goal is to (i) extend the existing 1D arterial network model (103 segments) of Reymond et al. to a more detailed model (143 segments) including the foot and hand circulation (Radial and Tibial arteries); (ii) use the extending model as testing tool for pOpmètre® (finger–toe pulse wave velocity). The arterial tree dimensions and properties were taken from the literature and completed with data from patient scans. A non-linear viscoelastic constitutive law for the arterial wall was considered. Comparison of simulations with & without detailed hand and foot circulation demonstrate important differences in waveforme morphology in the distal beds. The completed model predicts pressure and flow waves in the hand and foot arteries which are in good qualitative agreement with the published in-vivo measurements. The correlation between ftPWV and aPWV was good and significant (R2 = 0.95). The Bland and Altman analysis, mean difference was 0.4 m/s, classifying the ftPWV as good agreement with reference method.

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